One of the questions people often ask is are all drugs equally dangerous or are some more dangerous than others? This is a tricky question to answer because there are drugs that have very small consequences in the short run, but long health consequences in the long run. Among these would be tobacco has very little short term effect, except for on mood regulation; but in the long run is one of the more dangerous drugs in terms of causing cancer and other health consequences. In the short run, two of the most dangerous ones are heroine and other opiods, then methamphetamine. Heroine and methamphetamines are dangerous because they are very, very strong. They are not produced under controlled situations. The purity of heroine has gone up dramatically as the shift of supplies from Afghanistan. The purity went almost up to 100 percent, versus 20 years ago, it was often cut one and ten with other ingredients. Now, it's much easier to overdose on it. If you are buying from different suppliers, they may not be cutting it the same way, so you don't even know how much you need and there is not good product labeling. Methamphetamine is typically made in a lab with an inexperienced chemist. That chemist may or may not do it the same way, from one batch to another or from one chemist to another. You are never really sure how much you are getting. You are not really sure how they made it. As a consequence of methamphetamine, which is a very hard drug, is very hard to predict and much more likely to lead to an overdose or other kinds of consequences. It is, again, one that is associated very much with a psychotic break. Use of methamphetamines in particular, if you have a history of psychosis or other emotional problems, is much more likely to make those problems worse.